Recent research suggests that alterations in circadian rhythms, particularly in individuals with specific SNPs in clock-related genes like Signal transducer and activator of transcription 3 (STAT3), patatin-like phospholipase domain-containing 3 (PNPLA3), peroxisome proliferator-activated receptor-gamma (PPAR), and peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A), are linked to NAFLD development and progression[33]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.