Moreover, NAFLD is linked to specific alterations in liver transcription factors, such as sterol regulatory element-binding protein (SREBP), which regulates lipid production, carbohydrate-responsive element-binding protein (ChREBP), involved in glucose balance maintenance; and nuclear factor kappa B (NF-κb), associated with inflammatory responses[129]. This evidence concerns the gene MLXIPL and metabolic dysfunction-associated steatotic liver disease.