Contemporary lifestyles, often marked by factors such as nighttime exposure to artificial light, rotating night shift schedules, social jet lag, irregular sleep-wake cycles, and inconsistent eating patterns, frequently disrupt the natural rhythm of the circadian clock, leading to “circadian misalignment.” This phenomenon is believed to contribute to global health challenges, including obesity, non-alcoholic fatty liver disease (NAFLD), and non-alcoholic steatohepatitis (NASH)[33]. The gene discussed is CLOCK; the disease is metabolic dysfunction-associated steatohepatitis.