The main mechanism of ARS and its derivatives (ART, artemether, DHA) toward leukemia, multiple myeloma, and lymphoma cells comprises oxidative stress response, inhibition of proliferation, induction of various types of cell death as apoptosis, autophagy, ferroptosis, inhibition of angiogenesis, and signal transducers, such as NF-κB, MYC, amongst others (Mancuso et al., 2021b). The gene discussed is MYC; the disease is lymphoma.