TGFBR2 is deubiquitinated by USP11 to maintain the TGF-β signal pathway (Jacko et al., 2016) and the glycosylation of TGFBR2 enhances the radio-resistance and BC cell stemness (Sun et al., 2021); therefore, maintaining a normal TGF-β pathway is essential for cancer cell control. This evidence concerns the gene TGFBR2 and breast cancer.