PSEN1 and memory impairment: Balducci et al. (2018) (Balducci et al., 2018) investigated the effects of DOX in different models: transgenic APP/PS1 mice expressing abundant APP and mutant presenilin 1, and C57BL/6 mice with memory impairment induced by intracerebroventricular (i.c.v.)injection of synthetic Aβ42 oligomers (AβOs) in an acute model of AD.