In most cases, FH is caused by a mutation in the genes encoding the LDL receptor, apolipoprotein B (ApoB), or proprotein convertase subtilisin/kexin type 9 (PCSK9), leading to decreased hepatic uptake of LDL and consequently high levels of LDL-C in the circulation [15,16]. Here, PCSK9 is linked to familial hyperaldosteronism.