This emerging understanding of the gut’s role in psoriasis offers potential avenues for microbiota-targeted therapies to improve biologic treatment outcomes. Rheumatoid arthritis (RA), an autoimmune disorder characterized by joint inflammation, is influenced by genetic factors like the HLA-DRB1 gene as well as lifestyle factors such as smoking [5]. The gene discussed is HLA-DRB1; the disease is rheumatoid arthritis.