The trigeminal nerve plays a pivotal role in migraine pathophysiology, with key vasodilatory neuropeptides such as calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP) contributing to the onset of migraine through neurogenic inflammation and vascular dilation [5,6]. This evidence concerns the gene ADCYAP1 and migraine disorder.