Cazzaro et al. researched the functions that autophagy cargo receptors perform in the regulation of sEV release through pathways that alter AD development and discovered that autophagy cargo receptors, p62, and optineurin, inhibit sEV release, whose increase is mediated by AD pathogenic proteins, such as mutant tau and Aβ oligomers [224]. The gene discussed is MAPT; the disease is Alzheimer disease.