SNCA and Parkinson disease: Autophagy was inhibited, leading to an enhancement in the accumulation of potentially pathogenic oligomers of alpha-synuclein, This provides credence to the hypothesis that neuron autophagy is necessary for maintaining protein homeostatic balance and has both pathological and therapeutic significance for synucleinopathy as well as Parkinson's disease, determining the circumstances in which autophagy would not be adequate to break down alpha-syn aggregates [58,59].