ATG7 and Alzheimer disease: According to research conducted utilizing Atg7 knockout mice and cell cultures, microglia autophagy was discovered to have a unique function in the elimination of extracellular β-amyloid (Aβ) fibrils and regulation of the Aβ-elicited NLRP3 inflammasome, which were vital for Alzheimer's disease (AD) progression [80,81].