ITCH and hepatocellular carcinoma: On the other hand, the expression of circRNA-ITCH was reduced in HCC cell lines, and its overexpression might act as a tumor suppressor by sponging miR-7 or miR-214 to regulate the level of ITCH, which could inhibit the expression of c-Myc and cyclin D1 and suppress the Wnt/β-catenin signaling pathway [90].