Interestingly, in wild-type HCT16 CRC cells, Chk2 caused almost all Hu-antigen R–mRNA complexes to dissociate, and several Hu-antigen R-interacting mRNAs that encode apoptosis and proliferation-related proteins (TJP1, Mdm2, TP53BP2, Bax, and K-Ras) dissociated from Hu-antigen R, which enhanced cell survival28, 29, 30 (Fig. 2). Here, CHEK2 is linked to colorectal carcinoma.