LRP1 has a protective function against atherosclerosis through modulating ATP-binding cassette A1 (ABCA1) expression via extracellular regulated protein kinases 1/2 (ERK1/2)/cytosolic phospholipase A2 (cPLA2/)arachidonic acid (Graves et al., 1996; Lin et al., 1992), an inhibitor of ABCA1 expression driven by liver X receptors (LXR) (DeBose-Boyd et al., 2001). Here, ABCA1 is linked to atherosclerosis.