Epsins promote the development of atherosclerosis by preventing the ubiquitination and degradation of LRP-1 in macrophages and regulating calcium release from the ER by promoting the proteasomal degradation of IP3R1 through its ubiquitin interaction motif (UIM) in endothelial cells (Dong et al., 2020; Brophy et al., 2019). The gene discussed is LRP1; the disease is atherosclerosis.