Previous studies reported a decreased level of Septin 12 in men suffering from asthenozoospermia and correlated Septin 12 malfunction with sperm morphology abnormalities (Kuo et al., 2012; Ihara et al., 2005; Sugino et al., 2008; Lhuillier et al., 2009). The gene discussed is SEPTIN12; the disease is Reduced sperm motility.