Using the TCGA-BRCA dataset (normal = 114, tumor = 1104), significant downregulation of SAMD5 was observed (log2FC = -3.53, p = 7.057 × 10-92) and validated with integrated TCGA-BRCA/Genotype-Tissue Expression (GTEx) data (normal = 291, tumor = 1085) via Gene Expression Profiling Interactive Analysis (GEPIA2), confirming SAMD5's significantly lower expression in tumor tissues (Figure 2A). This evidence concerns the gene SAMD5 and neoplasm.