Regarding cell phenotypes, PLK1 overexpression facilitated cell viability (Figure 9C), colony formation (Figure 9D), and invasive capability (Figure 9E); additionally, PLK1 overexpression partially attenuated the effects of SAMD5 overexpression on cell viability, colony formation, and cell invasion (Figures 9C-9E) in breast cancer cells. This evidence concerns the gene SAMD5 and breast cancer.