PLK1 and breast cancer: Regarding the mechanism underlying SAMD5 function in breast cancer, the 258 genes of the HALLMARK_MYC_TARGETS_V1/V2 pathway were analyzed for factors correlated with SAMD5; 13 genes were found to be remarkably negatively correlated with SAMD5 (r < -0.40, p < 0.05), among which PLK1 had the strongest negative correlation (Figure 7A).