RT‐qPCR (Figure 6C), WB (Figure 6D), and immunofluorescence staining (Figure 6E; Figure S6B, Supporting Information) revealed a significant reduction in SOX9 expression in SW480 and LoVo CRC cells treated with CMD‐BHQ3‐PTL/DOX@RBCm in vitro. The gene discussed is SOX9; the disease is colorectal carcinoma.