The capacity of the nano‐delivery system to selectively locate these cells and exert its therapeutic effects represents a significant breakthrough.[32] This specificity is critical in suppressing stemness‐related processes, slowing tumor progression, and potentially offering a more nuanced and effective treatment approach for CRC.[50] Another distinctive feature of CMD‐BHQ3‐PTL/DOX@RBCm was its ability to downregulate SOX9 and induce YAP1 phosphorylation. This evidence concerns the gene SOX9 and colorectal carcinoma.