Subsequently, we intervened in CRC cells with SOX9‐KO using CMD‐BHQ3‐PTL/DOX@RBCm and assessed stemness in tumor cells using WB (Figure 6M; Figure S6E,F, Supporting Information), immunofluorescence experiments (Figure 6N), and correlation analysis (Figure 6O). The gene discussed is SOX9; the disease is colorectal carcinoma.