ETBF, a classic carcinogenic bacterium within the Bacteroides genus, has been extensively studied for its role in promoting proliferation, stemness, and metastasis of CRC.16,26,33 Integrating results of metagenomics, we hypothesized that KRAS mutations might facilitate the intratumoral colonization of ETBF in CRC, further enhancing carcinogenic effects. This evidence concerns the gene KRAS and colorectal carcinoma.