IRF7 and neoplasm: And transcription activation of IFNβ requires an enhancer containing IRF7,47–49 Furthermore, all elements of immunological function of IFNβ are controlled by IRF7.50 IRF7/IFNβ plays a crucial role in enhancing chemotherapy efficacy, preventing tumor recurrence, and boosting immune effects in CRC.51,52 In addition, IFNβ has been proven not only to activate immune cells but also to exhibit direct antimicrobial activity against staphylococcus aureus.53 However, whether IRF7/IFNβ can inhibit intratumoral colonization of ETBF in CRC remains unclear.