As is well known, the TLR signaling pathway acts as the “gatekeeper” of the human immune system, protecting the host from bacterial and other microbial invasions.45,46 In summary, these analyses suggest that miR3655/SURF6 may promote intratumoral colonization of ETBF in CRC by regulating the TLR signaling pathway. Here, SURF6 is linked to colorectal carcinoma.