KRAS G12D is the most common mutation site in CRC.36,37 To ascertain whether KRAS mutations could promote colonization of ETBF in CRC at the cellular level, we constructed CRC cell models with KRAS EV and corresponding KRAS G12D MUT in KRAS WT CRC cell lines (SW48 and RKO) (Figure 2(b)). This evidence concerns the gene KRAS and colorectal carcinoma.