We found 396 and 183 genes increased and decreased, respectively, in Smox–/– animals infected with H. pylori compared to uninfected controls; upregulated genes included those encoding for host response to bacterial infection (Wnt11, Saa3); downregulated genes included those involved in amino acid (Slc7a15, Mme) or nucleotide (Tubal3, Cda, Mpped2) metabolism, and regulation of transcription (Tbx18, Fabp1, Fbp1) and translation (Hsd17b13, Rdh16f2). Here, SMOX is linked to bacterial infectious disease.