Then, FVB/N INS-GAS mice, which are predisposed to develop dysplasia and intramucosal carcinoma (IMC) notably in response to H. pylori infection [21–23], were crossed to FVB/N Smox–/– mice to obtain FVB/N INS-GAS Smox–/– mice. This evidence concerns the gene SMOX and dysplasia.