Most downregulated pathways in the infected Smox–/– animals involved the immune system and cancer, such as “Migration of mononuclear leukocytes”, “Quantity of leukocytes”, “Immune response of cells” (Fig. 2B), and “Epithelial neoplasm” (Fig. 2C); the list of the genes corresponding to these pathways is provided in Supplementary Fig. 5A, B. This evidence concerns the gene SMOX and cancer.