CXCL8 and irritable bowel syndrome: Another research showed that EA suppressed the expression of inflammatory cytokines, such as IL-8, IFN-γ, and TNF-α and in water avoidance stress (WAS) induced IBS mice and alleviated pain by suppressing the expression of inflammatory cytokines, such as IL-8, IFN-γ, and TNF-α (Mengzhu et al. 2023).