STX11 mutation causes familial hemophagocytic lymphohistiocytosis type 4, which is a life-threatening disease characterized by severe hyperinflammation.8 Kögl et al. found that after infecting with lymphocytic choriomeningitis virus, Stx11-deficient mice displayed severely reduced degranulation and cytolytic activity of cytotoxic T lymphocytes and natural killer cells and exhibited all clinical symptoms of hemophagocytic lymphohistiocytosis.8 We found that STX11 is downregulated in IPF lung based on the data mining in GEO public database. The gene discussed is STX11; the disease is idiopathic pulmonary fibrosis.