Conversely, following an intraperitoneal insulin injection, blood glucose levels in the 53-week-old 3W-301L-dosed huR83C mice decreased with time (Fig. 8b), demonstrating that the edited mice were protected against an age-related insulin resistance, consistent with previous observations in the rAAV-treated G6pc-/- mice32. The gene discussed is INS; the disease is Insulin resistance.