We know that many of these proteins (e.g., ITGB2, IGFBP-1, CLEC5A) were also specifically associated with AD when compared to a group with non-AD dementia (Supplementary Material: Fig. 3) [2], and that all markers except IL7 correlated with CSF Aβ42 or (p)Tau levels (Supplementary Material: Fig. 4), overall supporting their association to AD pathophysiology. This evidence concerns the gene IGFBP1 and Alzheimer disease.