Furthermore, in patients with idiopathic pulmonary fibrosis (IPF), fibrotic mesenchymal progenitor cells autocrine IL-8 promotes the self-renewal of IPF mesenchymal progenitor cells and the proliferation and motility of the IPF mesenchymal progenitor cell differentiated from MSCs. This evidence concerns the gene CXCL8 and idiopathic pulmonary fibrosis.