The severity of the physio-affective phenome (CFS, depressive and anxiety dimensions), which represents a major dimension of Long COVID, is significantly predicted by increased IgM/IgA-synapsin, IgA/IgG-MBP, IgG-MOG, and CRP and AOPP levels. The gene discussed is CRP; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.