To unravel the potential underlying molecular links between Setd7 regulation and metastasis as well as the impact of CPH on metastasis through regulating cellular metabolic pathways and metabolites, the tumor tissue samples collected from Setd7 WT (model control), Setd7 KO, and Setd7 WT treated with CPH were assayed using LC/MS/MS to perform the metabolomic analysis. The gene discussed is CPE; the disease is neoplasm.