In our previous study, we observed that Setd7 knockdown decreased the colony formation in human prostate cancer PC-3 and LNCaP cells [19], and Ingenuity® Pathway Analysis of microarray data showed Setd7 KD attenuates cell growth/proliferative pathways and activates the cell apoptosis pathways [19, 20]. The gene discussed is SETD7; the disease is Familial prostate cancer.