ALDH1A2 and amyotrophic lateral sclerosis: After treatment, ALS mice showed a significant reduction in ALDH1A2 mRNA and protein levels in spinal cord tissues, while an upregulation of ALDH1A2 was observed in the APG-treated groups, especially at a dose of 80 mg/kg (Fig. 1C, D), highlighting a potential key role of ALDH1A2 in the protective effects of APG against ALS.