In addition, APG not only alleviated the increased levels of ROS and aldehyde markers MDA and 4-HNE and the decreased levels of SOD and ALDH in spinal cord tissues of ALS mice, but also substantially offset the exacerbating effects of sh-ALDH1A2 on these OS markers (Fig. 7D-H). This evidence concerns the gene LDHA and amyotrophic lateral sclerosis.