Therefore, we analyzed OS levels and aldehyde content in ALS mouse spinal cord tissues and observed that APG, especially at higher doses (80 mg/kg), at least partially restored high levels of OS (increased ROS, decreased SOD and ALDH) and aldehyde accumulation (increased MDA and 4-HNE) to normal levels, not only demonstrating APG’s role as an antioxidant in various diseases, but also establishing the central role of ALDH1A2 in APG’s alleviation of ALS symptoms. This evidence concerns the gene ALDH1A2 and amyotrophic lateral sclerosis.