ALS mice were randomly divided into groups (n = 6): an untreated ALS model group and treatment groups receiving APG (purchased from Sigma-Aldrich (MO, USA) at 40 mg/kg and 80 mg/kg); wild-type (WT) mice (n = 6) received no treatment or intervention; the sh-ALDH1A2-treated group received bilateral intraperitoneal injections of 100μL lentivirus at a titer of 2 × 109. Here, ALDH1A2 is linked to amyotrophic lateral sclerosis.