Currently, although there is no direct evidence to suggest an interaction between lncRNA AGAP2-AS1 and the five core genes, existing research has revealed that the downregulation of lncRNA AGAP2-AS1 could act as a key inhibitory factor in preeclampsia (PE) by competitively inhibiting JDP2 at the post-transcriptional level through miR-57428. The gene discussed is JDP2; the disease is preeclampsia.