Another study on renal cell carcinoma (RCC) revealed a different pathway, where IGF2BP3 stabilizes AGAP2-AS1, allowing it to competitively bind with miR-9-5p, consequently upregulating the expression of Thrombospondin-2 (THBS2) and activating the PI3K/AKT signaling pathway. This evidence concerns the gene IGF2BP3 and hereditary clear cell renal cell carcinoma.