Large genome-wide association studies and subsequent meta-analyses have provided robust data for at least 20 common single nucleotide polymorphisms (SNPs) linked to IPF with minor allele frequency of > 5%, further corroborating the association between IPF susceptibility and impaired host defense, mammalian target of rapamycin signaling, cell-to-cell adhesion, and telomere maintenance.2 The gene discussed is MTOR; the disease is idiopathic pulmonary fibrosis.