Other biomarkers such as serial values of KL-6, IL-35, SP-D, CXCL-4, C-reactive protein, and the combination of IL-6 and its soluble receptor have been suggested as predictors of lung function decline after implementation of immunosuppressants in CTD-ILDs.104, 105, 106, 107 Furthermore, a recent model aiming to predict treatment response to cyclophosphamide and mycophenolate mofetil in systemic sclerosis ILD has been published.108. This evidence concerns the gene SFTPD and interstitial lung disease.