The Prospective Observation of Fibrosis in the Lung Clinical Endpoints Study (PROFILE) study investigated epithelium-derived proteins in IPF and demonstrated that increased values of 4 serum biomarkers (SP-D, CA19-9, CA-125, and MMP-7) consistently were predictive of poor outcomes.64 The gene discussed is SFTPD; the disease is idiopathic pulmonary fibrosis.