It was also found that algal polysaccharides secreted by worms increase the number of rumenococci in the gut, which in turn inhibits the development of STZ-induced T1DM mice by inducing CD8+ Treg cells.82 Consistently, the number of rumenococci in the feces and the number of CD8+ Treg cells in peripheral blood mononuclear cells were positively correlated in T1DM patients, and both were lower than in normal controls.83 The gene discussed is CD8A; the disease is type 1 diabetes mellitus.