↓Orthotopic pancreatic tumor progression;↓Infiltration of M2 macrophages in the tumor;↓Population of M2 macrophages in the spleen;↑Infiltration of CD3+/CD8+ T cells in tumors;↓Infiltration of PMN-MDSCs into tumors;↓Number of PMN-MDSCs in the spleen;Restore NK cell activation;. Here, CD8A is linked to pancreatic neoplasm.