NFE2L2 and pemphigus foliaceus: There are more than 80 natural compounds that accumulate in Dahuang Danshen Decoction, including salvianolic acid A, emodin, baicalein, etc. Dahuang Danshen Decoction alleviates PF, pancreatic tissue oedema and the inflammatory response; regulates the kelch-like ECH-associated protein 1 (Keap-1)/nuclear erythroid-related factor 2 (Nrf2) pathway to alleviate OS damage caused by CP; enhances the body’s antioxidant capacity; and, to some extent, has a dose-dependent effect on improving endoplasmic reticulum stress and reducing PSCs activation and ECM synthesis and deposition (Liang et al.