SHANK3 and autism: In other models of autism, such as maternal high-fat diet (HFD), direct administration of L. reuteri ATCC-6475 to weanling males (P21 for 4 wk) failed to reverse repetitive behavior (Buffington et al. 2016) but was effective in adult males and females in a monogenetic Shank3 ASD model (Tabouy et al. 2018).