Additionally to their expression changes, LMTK2 has recently been predicted as an Alzheimer’s disease risk gene by computational analysis of genome-wide association studies while LMTK1 has been identified as a haplotype-associated risk factor of ALS/FTD and de novo copy number variation of LMTK1 in sporadic ALS also has been reported [126–128]. This evidence concerns the gene LMTK2 and early-onset autosomal dominant Alzheimer disease.