Perturbed cdk5/p35 transport can lead to defective synaptic functions seen in neurodegenerative diseases by deregulating cdk5-dependent pre- and postsynaptic processes such as neurotransmitter release, control of postsynaptic neurotransmitter receptor expression and clustering, and modulation of dendritic spine morphogenesis [3]. The gene discussed is CDK5; the disease is neurodegenerative disease.