Supporting this notion, a recent study has found negative correlation between reduced LMTK2 levels and increased tau phosphorylation in Alzheimer’s disease [194], however, the direct mechanistic link between loss of LMTK2, increased GSK3β activity and tau hyperphosphorylation requires further investigation to confirm this concept. This evidence concerns the gene LMTK2 and early-onset autosomal dominant Alzheimer disease.