Although previous reports showed TBK1 negatively regulates senescence or aging‐related neurodegenerative diseases,[14, 15] there is also evidence suggesting that TBK1 can promote cellular senescence[47] and age‐related Alzheimer's disease (AD).[16] These findings suggest that the regulation of TBK1 on senescence is multifaceted. Here, TBK1 is linked to Alzheimer disease.