The ATPase family AAA domain‐containing 3A (ATAD3A), a mitochondrial protein that regulates nucleoid organization, and cholesterol metabolism, serves as a scaffold to maintain the integrity of mitochondrial membrane structure.[20, 21, 22, 23] Our previous findings demonstrate that ATAD3A acts as a suppressor of Pink1‐mediated mitophagy and plays a key role in maintaining hematopoietic homeostasis and tumor chemoimmunotherapy resistance.[24, 25] However, the role of ATAD3A in the aging process is poorly understood. This evidence concerns the gene ATAD3A and neoplasm.