Hydroxycamptothecin (HCPT) is a kind of DNA synthesis inhibitor, and its mechanism of action is mainly through acting on the S phase of the cell cycle, binding with DNA topoisomerase I (Topo I), interfering with the processes of DNA replication, transcription, and repair, causing the apoptosis of tumor cells, and ultimately achieving the purpose of anti-tumor [1]. Here, TOP1 is linked to neoplasm.