Indeed, as a co-chaperone of the 70 kDa heat shock protein (HSP70), involving its conserved BAG domain, BAG3 governs protein homeostasis activating autophagy, promoting the clearance of misfolded protein, and suppressing apoptosis, thus becoming a focus of research as a potential target for cancer therapies [1,2,3,4]. The gene discussed is BAG3; the disease is cancer.