Kim S et al. 2019 reported the anti-tumor and apoptotic effects are elicited by quercetin through the regulation of MAPK pathways by increasing the levels of Bax, cleaved-PARP, p-JNK, p-p38, and p-ERK1/2, while reducing Bcl-2 in A375SM melanoma cells [49]. This evidence concerns the gene MAPK8 and melanoma.