CASP3 and familial pancreatic carcinoma: In fact, SFN has already been documented to force apoptosis in pancreatic cancer cells via caspase-3 cleavage [52], and Habib et al. recently documented synergistic effects of the chemotherapeutic agent paclitaxel and SFN on prostate cancer cell apoptosis, triggered by altering Bax and Bcl-2 protein expression and caspase-3 cleavage [53].