The IVW analysis indicated a positive causal association between transferrin and AMD (whether dry or wet) (OR = 1.167, 95% CI = 1.045–1.304, p = 0.006), and between transferrin and wet AMD (OR = 1.194, 95% CI = 1.018–1.402, p = 0.030). This evidence concerns the gene TF and wet macular degeneration.