In this work, we show that persimmon leaf extract is effective in reducing viability of two different CRC cell lines: E705 cells, representative of most CRC patients being KRAS, NRAS, or BRAF wild type but carrying a silent mutation in the PIK3CA gene, and SW480 cells, carrying a KRAS activating mutation which normally leads to a less common but more aggressive form of CRC. Here, KRAS is linked to colorectal carcinoma.