In the MDA-MB-231 breast cancer cell line (ER−/PR−/HER2−, EGFR+), curcumin reduced ERK phosphorylation, while apigenin inhibited tyrosine phosphorylation of HER2 and reduced the expression of phospho-JAK1 and phospho-STAT3. The gene discussed is MAPK1; the disease is breast carcinoma.