ABCC1 and osteosarcoma: Similarly, Zhao et al. [88] demonstrated that poncirin (2.5 to 80 μM), a flavanone glycoside, increased sensitivity to cisplatin (8 μM) in cisplatin-resistant osteosarcoma cells by downregulating the expression of MDR-1, MRP1 (ABCC1), and BCRP, and inhibiting the PI3K/Akt signaling pathway.