On the other hand, other authors suggest that propolis and its components are effective in controlling allergic diseases because many antioxidants inhibit the degranulation of mast cells and the release of histamine, tryptase, leukotriene, prostaglandin D2, and granulocyte and macrophage colony-stimulating factor (GM-CSF), IL-6, IL-8, and other mediators of inflammation. The gene discussed is CSF2; the disease is allergic disease.