BCL2 and cancer: The presence of constitutively active NF-κB is a common underlying factor in inflammation-related cancers, and it leads to the constitutive expression of various prosurvival genes, including (i) anti-apoptotic genes like Bcl-2 and Bcl-xL; (ii) proangiogenic gene VEGF; and (iii) genes that encode proteins involved in metastasis and invasion, such as MMPs.