Flavonoids, such as genistein, hesperidin, naringenin, flavokawain A, icariin, baicalein, wogonin, apigenin, CAPE, resveratrol, EGCG, luteolin, fisetin, norwogonin, methyl gallate, catechin-3-O-gallate, ursolic acid, and betulinic acid, and kaempferol, have been shown to resensitize tumor cells to chemotherapy by interfering with the NF-κB signaling pathway. The gene discussed is NFKB1; the disease is neoplasm.