AGER and familial pancreatic carcinoma: Additionally, quercetin at various concentrations (6.25, 12.5, 25, and 50 mM) promoted cell death and enhanced gemcitabine (500 nM) sensitivity in human pancreatic cancer MIA Paca-2 and MIA Paca-2 (GEM-resistant) cells by targeting the receptor for advanced glycation end products (RAGE)/PI3K/AKT/mTOR axis, particularly through RAGE inhibition.