Similarly, oleanolic acid induced the phosphorylation of p38, ERK, and JNK, resulting in caspases and PARP cleavage, as well as the release of cytochrome C. Furthermore, this study confirmed that the apoptosis induced by oleanolic acid is due to the activation of p38 signaling pathways in several types of tumor cells [40]. This evidence concerns the gene MAPK8 and neoplasm.