It contains caffeine, chlorogenic acids (CGAs), caffeic, p-coumaric, vanillic, ferulic, protocatechuic acids, coffeasterin, kaempferol, quercetin, sinapic, quinolic, tannic, pyrogallic acids, trigonelline, caffeoylquinic, and dicaffeoylquinic, which substantially mitigate hyperglycemia and α-glucosidase activity and enhance insulin secretion [298,299,300]. This evidence concerns the gene INS and Hyperglycemia.