Moreover, inflammatory makers [white blood cells, erythrocyte sedimentation rate (ESR), ferritin], insulin sensitivity parameters (insulin concentration, HbA1C, HOMA-IR), and cardiometabolic risk factor parameters (uric acid, triglycerides, LDL, Apo-B) were significantly higher, while HDL, Apo-A, and 25-OH-vitamin D concentrations were significantly lower in subjects with obesity compared to those with overweight and normal BMI. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.