This process may stimulate major intracellular inflammatory pathways through increased expression of inflammatory factors involved in insulin resistance, such as protein kinase C (PKC), c-Jun N-terminal kinase (JNK), and the IκB kinase (IKK) complex that activates nuclear factor kappa B (NF-κB) in the cytoplasm. The gene discussed is NFKB1; the disease is Insulin resistance.