The aim of our study was to determine the concentrations of the adipokines apelin-12, vaspin and resistin in children and adolescents with overweight and obesity before and after the implementation of a 1-year personalized multidisciplinary lifestyle intervention program of diet, sleep and physical activity, and to explore their associations with lipid and glucose metabolism. This evidence concerns the gene RETN and obesity due to melanocortin 4 receptor deficiency.