Low ω-6 to ω-3 polyunsaturated fatty acid ratio diet. This diet, which was carefully investigated in 17 adolescent subjects with non-alcoholic fatty liver disease (NAFLD), overweight, and type 2 diabetes, provided an interesting insight into the impact of a low ω-6 to ω-3 PUFA ratio on insulin clearance both during fasting and after meals [53]. This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.