Moreover, krill oil ameliorates high-fat diet-induced cognitive impairment by reducing oxidative stress in the brain, including reactive oxygen species (ROS), lipid peroxidation, and nitric oxide (NO) [18], and phospholipids from Antarctic krill stimulate the expression of fatty acid synthetase (FAS), and peroxisome proliferator-activated receptor alpha (PPAR-α) in liver tissue. This evidence concerns the gene PPARA and Cognitive impairment.