According to a meta-analysis by Silva et al. (2023), Bcl-2 protein overexpression is linked to worse lymph node metastasis, overall survival, and disease-free survival in patients with HNC though, it is important to note that this conclusion may not be entirely reliable due to the variability of included studies [38]. The gene discussed is BCL2; the disease is metastatic malignant neoplasm in the lymph nodes.