MGMT and colorectal carcinoma: In the same previous study, we found that a deficient DNA repair pathway characterized by MGMT and MMR methylation and/or LOH followed by Wnt gene mutations was predominant at the somatic level, in the proximal/whole-colon SP-FHP/CRC, and we have previously suggested that colonic mucosa with Paneth cell metaplasia may be one of the pre-neoplastic lesions in the development of proximal/whole-colon SPS-FHP/CRC [19].