MGMT and colorectal carcinoma: We also proposed that two forms of SPS-FHP/CRC appear to exist, proximal/whole-colon and distal SPS-FHP/CRC, according to the preferential location of the lesions and the somatic events involved in tumor initiation: MGMT and mismatch repair (MMR) gene defects, followed by Wnt gene mutations in the former and mutations in the RAS/RAF genes in the latter.