HAND2 and neoplasm: Thus, it appears that in metastatic cells that have separated from the primary tumor and migrated into the abdominal cavity, a partial transition of EMT occurs, which is accompanied by a decrease in the methylation level of five lncRNA genes: HAND2-AS1, KCNK15-AS1, MEG3, SEMA3B-AS1, and ZNF667-AS1.