Methylation levels of ten lncRNA genes (GAS5, HAND2-AS1, KCNK15-AS1, MAGI2-AS3, MEG3, SEMA3B-AS1, SNHG6, SSTR5-AS1, ZEB1-AS1, and ZNF667-AS1) were determined in 140 EOC samples with and without metastases (T), 123 matched histologically normal tissue samples (N), 59 peritoneal metastases (PM), and 18 ovarian tissue samples from post-mortem “donors” with no history of cancer (D) (Figure 1a). This evidence concerns the gene HAND2 and cancer.