At the same time, baseline blood NfL levels in FTD have been correlated with more prominent (cross-sectionally) and accentuated (longitudinally) global and focal frontotemporal atrophy, worse cognitive performance, behavioral disturbances, and functional impairment, more abrupt cognitive, behavioral, and functional decline, as well as shorter survival [43,48,49,50,52,53,54,56,57,63,64,65,66,67,68]. This evidence concerns the gene NEFL and frontotemporal dementia.