For instance, homozygous ADCY3 pathogenic variants lead to severe obesity in the Pakistani population [5], a Swedish study of 630 men found that variants in the ADCY3 gene confer risk to obesity [8], and some ADCY3 variants are associated with adult-onset obesity in the Chinese Han population [9]. The gene discussed is ADCY3; the disease is obesity due to melanocortin 4 receptor deficiency.